LymphedemaV1, Main, Exploration, bibRecord, 001D81

Fibrosis worsens chronic lymphedema in rodent tissues

Identifieur interne : 001D81 ( Main/Exploration ); précédent : 001D80; suivant : 001D82

Fibrosis worsens chronic lymphedema in rodent tissues

Auteurs : Laura L. Lynch ; Uziel Mendez ; Anna B. Waller ; Amani A. Gillette ; Roger J. Guillory ; Jeremy Goldman

Source :

American Journal of Physiology - Heart and Circulatory Physiology [ 0363-6135 ] ; 2015.

RBID : PMC:4436986

Descripteurs français

KwdFr :
- Animaux, Bléomycine (toxicité), Femelle, Fibrose (anatomopathologie), Fibrose (physiopathologie), Fibrose (étiologie), Inflammation (anatomopathologie), Inflammation (physiopathologie), Lymphadénectomie (effets indésirables), Lymphoedème (anatomopathologie), Lymphoedème (physiopathologie), Rat Sprague-Dawley, Rats, Souris, Souris de lignée BALB C, Système lymphatique (), Système lymphatique (anatomopathologie), Système lymphatique (physiopathologie).
MESH :
- anatomopathologie : Fibrose, Inflammation, Lymphoedème, Système lymphatique.
- effets indésirables : Lymphadénectomie.
- physiopathologie : Fibrose, Inflammation, Lymphoedème, Système lymphatique.
- toxicité : Bléomycine.
- étiologie : Fibrose.
- Animaux, Femelle, Rat Sprague-Dawley, Rats, Souris, Souris de lignée BALB C, Système lymphatique.

English descriptors

KwdEn :
- Animals, Bleomycin (toxicity), Female, Fibrosis (etiology), Fibrosis (pathology), Fibrosis (physiopathology), Inflammation (pathology), Inflammation (physiopathology), Lymph Node Excision (adverse effects), Lymphatic System (drug effects), Lymphatic System (pathology), Lymphatic System (physiopathology), Lymphedema (pathology), Lymphedema (physiopathology), Mice, Mice, Inbred BALB C, Rats, Rats, Sprague-Dawley.
MESH :
- chemical , toxicity : Bleomycin.
- adverse effects : Lymph Node Excision.
- drug effects : Lymphatic System.
- etiology : Fibrosis.
- pathology : Fibrosis, Inflammation, Lymphatic System, Lymphedema.
- physiopathology : Fibrosis, Inflammation, Lymphatic System, Lymphedema.
- Animals, Female, Mice, Mice, Inbred BALB C, Rats, Rats, Sprague-Dawley.

Abstract

Secondary lymphedema in humans is a common consequence of lymph node dissection (LND) to treat breast cancer. A peculiar characteristic of the disease is that lifelong swelling often precipitously appears several years after the surgical treatment, often due to an inflammatory stimulus. Although the incidence of secondary lymphedema dramatically increases after radiation therapy, the relationship between fibrotic scarring and the eventual appearance of lymphedema remains unclear. To clarify the role of fibrosis in secondary lymphedema initiation, we chemically increased fibrosis in rodent tissues with bleomycin and assessed the ability of the local lymphatic system to prevent lymphedema, either acutely or in a chronic state induced by inflammation. We found that bleomycin injections exacerbated fibrotic matrix deposition in an acute mouse tail lymphedema model (P < 0.005), reduced wound closure (P < 0.005), and impaired the ability of tail lymphatics to regenerate (P < 0.005) and reduce the swelling (P < 0.05). When fibrosis was worsened with bleomycin after axillary LND in the rat foreleg, the ability of the foreleg lymphatic system to reduce the chronic state swelling induced by stimulated inflammation was severely impaired (P < 0.005). Indocyanine green lymphography in axillary LND-recovered rat forelegs revealed a worsened lymphatic drainage due to inflammation and bleomycin pretreatment. Although inflammation reduced the drainage of dextran fluid tracer from control forelegs (P < 0.05), the reduction in fluid drainage was more severe after axillary LND when fibrosis was first increased (P < 0.005). These findings demonstrate that fibrosis reduces the lymphatic capacity to functionally regenerate and prevent the chronic appearance of lymphedema.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436986

DOI: 10.1152/ajpheart.00527.2013
PubMed: 25770241
PubMed Central: 4436986

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Fibrosis worsens chronic lymphedema in rodent tissues</title>
<author><name sortKey="Lynch, Laura L" sort="Lynch, Laura L" uniqKey="Lynch L" first="Laura L." last="Lynch">Laura L. Lynch</name>
</author>
<author><name sortKey="Mendez, Uziel" sort="Mendez, Uziel" uniqKey="Mendez U" first="Uziel" last="Mendez">Uziel Mendez</name>
</author>
<author><name sortKey="Waller, Anna B" sort="Waller, Anna B" uniqKey="Waller A" first="Anna B." last="Waller">Anna B. Waller</name>
</author>
<author><name sortKey="Gillette, Amani A" sort="Gillette, Amani A" uniqKey="Gillette A" first="Amani A." last="Gillette">Amani A. Gillette</name>
</author>
<author><name sortKey="Guillory, Roger J" sort="Guillory, Roger J" uniqKey="Guillory R" first="Roger J." last="Guillory">Roger J. Guillory</name>
</author>
<author><name sortKey="Goldman, Jeremy" sort="Goldman, Jeremy" uniqKey="Goldman J" first="Jeremy" last="Goldman">Jeremy Goldman</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25770241</idno>
<idno type="pmc">4436986</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436986</idno>
<idno type="RBID">PMC:4436986</idno>
<idno type="doi">10.1152/ajpheart.00527.2013</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">000245</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000245</idno>
<idno type="wicri:Area/Pmc/Curation">000245</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000245</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001251</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001251</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000F90</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F90</idno>
<idno type="wicri:Area/PubMed/Curation">000F90</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000F90</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000F90</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000F90</idno>
<idno type="wicri:Area/Ncbi/Merge">007138</idno>
<idno type="wicri:Area/Ncbi/Curation">007138</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">007138</idno>
<idno type="wicri:doubleKey">0363-6135:2015:Lynch L:fibrosis:worsens:chronic</idno>
<idno type="wicri:Area/Main/Merge">001D84</idno>
<idno type="wicri:Area/Main/Curation">001D81</idno>
<idno type="wicri:Area/Main/Exploration">001D81</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Fibrosis worsens chronic lymphedema in rodent tissues</title>
<author><name sortKey="Lynch, Laura L" sort="Lynch, Laura L" uniqKey="Lynch L" first="Laura L." last="Lynch">Laura L. Lynch</name>
</author>
<author><name sortKey="Mendez, Uziel" sort="Mendez, Uziel" uniqKey="Mendez U" first="Uziel" last="Mendez">Uziel Mendez</name>
</author>
<author><name sortKey="Waller, Anna B" sort="Waller, Anna B" uniqKey="Waller A" first="Anna B." last="Waller">Anna B. Waller</name>
</author>
<author><name sortKey="Gillette, Amani A" sort="Gillette, Amani A" uniqKey="Gillette A" first="Amani A." last="Gillette">Amani A. Gillette</name>
</author>
<author><name sortKey="Guillory, Roger J" sort="Guillory, Roger J" uniqKey="Guillory R" first="Roger J." last="Guillory">Roger J. Guillory</name>
</author>
<author><name sortKey="Goldman, Jeremy" sort="Goldman, Jeremy" uniqKey="Goldman J" first="Jeremy" last="Goldman">Jeremy Goldman</name>
</author>
</analytic>
<series><title level="j">American Journal of Physiology - Heart and Circulatory Physiology</title>
<idno type="ISSN">0363-6135</idno>
<idno type="eISSN">1522-1539</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Bleomycin (toxicity)</term>
<term>Female</term>
<term>Fibrosis (etiology)</term>
<term>Fibrosis (pathology)</term>
<term>Fibrosis (physiopathology)</term>
<term>Inflammation (pathology)</term>
<term>Inflammation (physiopathology)</term>
<term>Lymph Node Excision (adverse effects)</term>
<term>Lymphatic System (drug effects)</term>
<term>Lymphatic System (pathology)</term>
<term>Lymphatic System (physiopathology)</term>
<term>Lymphedema (pathology)</term>
<term>Lymphedema (physiopathology)</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Rats</term>
<term>Rats, Sprague-Dawley</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Bléomycine (toxicité)</term>
<term>Femelle</term>
<term>Fibrose (anatomopathologie)</term>
<term>Fibrose (physiopathologie)</term>
<term>Fibrose (étiologie)</term>
<term>Inflammation (anatomopathologie)</term>
<term>Inflammation (physiopathologie)</term>
<term>Lymphadénectomie (effets indésirables)</term>
<term>Lymphoedème (anatomopathologie)</term>
<term>Lymphoedème (physiopathologie)</term>
<term>Rat Sprague-Dawley</term>
<term>Rats</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Système lymphatique ()</term>
<term>Système lymphatique (anatomopathologie)</term>
<term>Système lymphatique (physiopathologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Bleomycin</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Lymph Node Excision</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Fibrose</term>
<term>Inflammation</term>
<term>Lymphoedème</term>
<term>Système lymphatique</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Lymphatic System</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Lymphadénectomie</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Fibrosis</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Fibrosis</term>
<term>Inflammation</term>
<term>Lymphatic System</term>
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Fibrose</term>
<term>Inflammation</term>
<term>Lymphoedème</term>
<term>Système lymphatique</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Fibrosis</term>
<term>Inflammation</term>
<term>Lymphatic System</term>
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Bléomycine</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Fibrose</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Female</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Rats</term>
<term>Rats, Sprague-Dawley</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Femelle</term>
<term>Rat Sprague-Dawley</term>
<term>Rats</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Système lymphatique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Secondary lymphedema in humans is a common consequence of lymph node dissection (LND) to treat breast cancer. A peculiar characteristic of the disease is that lifelong swelling often precipitously appears several years after the surgical treatment, often due to an inflammatory stimulus. Although the incidence of secondary lymphedema dramatically increases after radiation therapy, the relationship between fibrotic scarring and the eventual appearance of lymphedema remains unclear. To clarify the role of fibrosis in secondary lymphedema initiation, we chemically increased fibrosis in rodent tissues with bleomycin and assessed the ability of the local lymphatic system to prevent lymphedema, either acutely or in a chronic state induced by inflammation. We found that bleomycin injections exacerbated fibrotic matrix deposition in an acute mouse tail lymphedema model (<italic>P</italic>
 < 0.005), reduced wound closure (<italic>P</italic>
 < 0.005), and impaired the ability of tail lymphatics to regenerate (<italic>P</italic>
 < 0.005) and reduce the swelling (<italic>P</italic>
 < 0.05). When fibrosis was worsened with bleomycin after axillary LND in the rat foreleg, the ability of the foreleg lymphatic system to reduce the chronic state swelling induced by stimulated inflammation was severely impaired (<italic>P</italic>
 < 0.005). Indocyanine green lymphography in axillary LND-recovered rat forelegs revealed a worsened lymphatic drainage due to inflammation and bleomycin pretreatment. Although inflammation reduced the drainage of dextran fluid tracer from control forelegs (<italic>P</italic>
 < 0.05), the reduction in fluid drainage was more severe after axillary LND when fibrosis was first increased (<italic>P</italic>
 < 0.005). These findings demonstrate that fibrosis reduces the lymphatic capacity to functionally regenerate and prevent the chronic appearance of lymphedema.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Gillette, Amani A" sort="Gillette, Amani A" uniqKey="Gillette A" first="Amani A." last="Gillette">Amani A. Gillette</name>
<name sortKey="Goldman, Jeremy" sort="Goldman, Jeremy" uniqKey="Goldman J" first="Jeremy" last="Goldman">Jeremy Goldman</name>
<name sortKey="Guillory, Roger J" sort="Guillory, Roger J" uniqKey="Guillory R" first="Roger J." last="Guillory">Roger J. Guillory</name>
<name sortKey="Lynch, Laura L" sort="Lynch, Laura L" uniqKey="Lynch L" first="Laura L." last="Lynch">Laura L. Lynch</name>
<name sortKey="Mendez, Uziel" sort="Mendez, Uziel" uniqKey="Mendez U" first="Uziel" last="Mendez">Uziel Mendez</name>
<name sortKey="Waller, Anna B" sort="Waller, Anna B" uniqKey="Waller A" first="Anna B." last="Waller">Anna B. Waller</name>
</noCountry>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001D81 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001D81 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4436986
   |texte=   Fibrosis worsens chronic lymphedema in rodent tissues
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:25770241" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

Serveur d'exploration sur le lymphœdème

Fibrosis worsens chronic lymphedema in rodent tissues

Fibrosis worsens chronic lymphedema in rodent tissues

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.